Advanced vitamin D topics - some people need much more D3 than
normal, to suppress rheumatoid arthritis, multiple sclerosis, psoriasis
etc.; newly discovered vitamin D compoundsThis page is not at all complete. I intend to add
discussion of the articles listed below, and others, probably in September.
Before reading this page, please familiarise yourself with the research articles I link to and discuss at:
This page assumes a strong interest in biology and treatment
arrangements which go not only beyond many MD's limited knowledge of
vitamin D, but also beyond a properly informed knowledge of the needs
for most people for D3 supplementation to enable the immune
system to work well, as described in the above-mentioned page.
If you have this strong interest, a reasonable knowledge of biology and
the ability to make your own decisions, even tentatively so, about your
own and your family's health, then you might like to join the Nutrition
for Immune System Health (NISH) email discussion list: https://NISH.groups.io
. This is a high-signal-to-noise ratio discussion group with MDs
and nurses (only one so far), leading vitamin D researchers (many of whom are MDs),
nutritionists, as well as autodidacts such as myself with no formal
../ To the main page of this site.
Robin Whittle email@example.com 23 July 2021 Twitter: https://twitter.com/RobinWhittle3
(First established 2021-07-16.)
You are reading the best efforts of an
electronic technician and computer programmer. What I write
will hopefully help you understand the research, but should not be
mistaken for medical advice. Medical advice is what you get after
a doctor has examined you. Even if I was a doctor, I haven't
Don't take my word for anything. Please read the research
articles I cite - or at least their abstracts and my summaries.
If you don't understand them, please ask your doctor or other
healthcare professional to read them and advise you.
Quick intro and some articles of interest
The articles linked to from the ../05-mds/
page are broadly sufficient to understand everyone's need for
circulating 25-hydroxyvitamin D levels of 50ng/ml 125nmol/L
or more, in order
that the immune system can work properly. This is normally best
achieved with supplemental vitamin D3, though in emergencies, a single,
small, oral dose of calcifediol repletes these levels in about 4
is the name most commonly used for 25-hydroxyvitamin D as a pharmaceutical.
This applies directly to humans, but much the same is true of companion
and agricultural non-human animals - who, without proper
supplementation - may not be getting the D3 they need to be healthy.
After completing this page, I plan to write another page linking to and
discussing research articles on vitamin D toxicity.
This page concerns:
- D3 supplementation interventions to suppress
auto-immune inflammatory conditions, including those mentioned in the
title of this page.
- Cell-biology and molecular biology research and hypotheses
regarding the mechanisms by which higher than normal D3 supplemental
intakes might give rise to such suppression.
- The genetic and evolutionary background for the genetically
variable proclivity of humans (and other mammals) to have
self-destructively overly-inflammatory immune responses when we are not
infested by helminths (intestinal worms). Please see this section
for links to some relevant research articles: https://aminotheory.com/cv19/#helminthsgone and the use of deliberately introduced helminths to suppress these conditions (helminthic therapy).
- Intriguing new research concerning other aspects of vitamin D
biology which are beyond the three compounds I refer to as "vitamin D":
D3 cholecalciferol, 25-hydroxyvitamin D 25OHD calcifediol (AKA "calcidiol" -
but this should be avoided since it sounds too much like "calcitriol")
and 1,25-dihydroxyvitamin D calcitriol. (There are another three
matching compounds starting with vitamin D2, but D3 is the natural and
more effective base compound.)
This includes sulphates of 25-hydroxyvitamin D and a derivative of D3 -
20S-hydroxyvitamin D - which is the subject of current research.
I can't write about all this yet, since I need to carefully read the articles first!
Regarding higher than normal D3 intakes to suppress autoimmune overly-inflammatory conditions:
The Coimbra Protocol
This was developed by Dr Cicero Coimbra
in Brazil to suppress MS (Multiple Sclerosis) and potentially other
autoimmune diseases. I know two people who have used this
approach to successfully suppress extremely debilitating rheumatoid
Patrick McCullough and colleagues in Ohio
Dr McCullough takes 1.25mg 50,000IU D3
a day to suppress psoriasis. He and his colleagues research
healthy D3 intakes for most people, and the much higher intakes which
(with suitable medical supervision) suppress a variety of auto-immune
Topical Vitamin D, Sunshine, and UVB Phototherapy Safely
Control Psoriasis in Patients with Normal Pretreatment Serum
25-hydroxyvitamin D Concentrations: A Literature Review and
Discussion of Health Implications
Pete Batcheller - cluster headaches and migraine
The above two MDs are world leaders in
clinical research regarding higher than normal D3 intakes to suppress
MS, rheumatoid arthritis, psoriasis etc. - all of which are well known
to be caused by excessive inflammation.
Pete Batcheller (Washington State, USA) is another such pioneer, though
he has no medical qualifications. He has a chemistry degree and
is a retired US Navy fighter pilot and commander. His research
and outreach was prompted by his own debilitating cluster
He has helped several thousand cluster headache and migraine sufferers
suppress their symptoms with a protocol which resembles that of Dr
Coimbra - with whom he later corresponded. The link between
excessive inflammation and his own cluster headaches was made clear in
after he cleared the windscreen of his pickup truck of a layer of
pollen which had settled there. His D3, boron and other nutrients
protocol had kept the CHs in abeyance for years, but they returned with
a vengeance within hours of this gross pollen insult to his immune
Pete Batcheller's success in largely suppressing these awful
conditions, with the help of people who he communicates with via his
website, shows that there are significant human health problems which
are not yet solved by MDs and professional researchers, but which are
amenable solution to imaginative, highly motivated people who lack
Here are some of the new articles I want to read and discuss on this page.
Helminths downmodulate inflammatory responses
Lack of helminthic down-modulation of overly inflammatory
immune responses, evolved to counter such down-modulation, is a
likely component of the etiology of these diseases:
bi-functional molecule, tuftsin-phosphorylcholine (TPC),
ameliorates an established murine arthritis
Miri Blank, Tomer Bashi, Jordan Lachnish, Dana Ben-Ami-Shor,
Shovman, Mati Fridkin, Miriam Eisenstein, Alexander Volkov,
Barshack and Yehuda Shoenfeld.
PLoS One 2018-08-08
Some people find relief by the introduction of helminths: https://helminthictherapywiki.org
Mechanisms by which higher than normal D3 intakes might help suppress auto-immune hyper-inflammatory diseases
D Resistance as a Possible Cause of Autoimmune Diseases: A Hypothesis
Confirmed by a Therapeutic High-Dose Vitamin D Protocol
, Rainer Johannes Klement, Felix Schweiger, Beatrix Schweiger and Jörg Spitz
Frontiers in Immunology 2021-04-07
An older Crohn's disease article. I want to find some more recent ones too. See the articles which cite this one:
Recently discovered - or at least little known to MDs - but potentially significant vitamin D compounds
Add a hydroxyl group to the 20th carbon in D3 and . . .
20S-Hydroxyvitamin D3, a Secosteroid Produced in Humans, Is Anti-Inflammatory and Inhibits Murine Autoimmune Arthritis
Arnold E. Postlethwaite
, Robert C. Tuckey, Tae-Kang Kim, Wei Li, Syamal
K. Bhattacharya, Linda K. Myers, David D. Brand, and Andrzej T.
Frontiers in Immunology 2021-06-30
Sulphated 25-hydroxyvitamin D is prevalent in the circulation:
Regulation of circulating 25-hydroxyvitamin D levels by enzymes
which degrade it, at rates approximately proportional to its
concentration, forming a negative feedback system which makes it harder
to raise higher levels than lower levels
I have a general idea that this works, but would like to know a lot
more about the mechanisms and to what extent they are affected by and
affect D3 levels - and more broadly conversion of D3 to 25OHD in cells
outside the liver.
See the above-mentioned article: The serum vitamin D metabolome . . . .
Connections between Rheumatoid Arthritis (RA), psoriasis and
potentially other conditions - and some cell-biology hypotheses of
Perhaps there is a way of connecting tenuous knowledge of:
- Helminthic down-modulation of inflammatory immune responses.
- High levels of supplemental D3 - with consequent high levels of
25-hydroxyvitamin D and potentially other less well known compounds.
- Research on citrullination and resultant antibodies and inflammatory immune responses.
These are all deep and developing fields. I expect my rabbit-hole
alarm to go off frequently. Hopefully I will find something
interesting without being lost interminably in the warrens.
involves an enzyme modifying an arginine amino acid when it is part of
a protein. An NH ketamine group is replaced with an O ketone
group, both doubly bonded to the molecule. This changes the
arginine into citrulline, which is not a protein building amino
acid. The behaviour of the whole protein changes in several ways,
and this can trigger the production of antibodies and then those
antibodies attaching to said proteins, triggering a cell-destroying
The articles below also concern some aspects of the HLA-DR [WP
which may be involved in both RA and worse outcomes in COVID-19.
(I am yet to read these articles, except the last: Martin et al. 2021.)
How citrullination invaded rheumatoid arthritis research
Walther J van Venrooij
& Ger JM Pruijn
Arthritis Research & Therapy 2014-01-29
Functional and Structural Characterization of a Novel HLA-DRB1*04:01-Restricted α-Enolase T Cell Epitope in Rheumatoid Arthritis
Dubnovitsky, Charlotta Sandin, Genadiy Kozhukh, Hannes Uchtenhagen,
Eddie A. James, Johan Rönnelid, Anders Jimmy Ytterberg, Jennifer
Pieper, Evan Reed, Karolina Tandre, Mary Rieck, Roman A. Zubarev, Lars
Rönnblom, Tatyana Sandalova, Jane H. Buckner, Adnane Achour and
Frontiers in Immunology 2016-11-14
Progression on Citrullination of Proteins in Gastrointestinal Cancers
and Yingyan Yu
Frontiers in Oncology 2019-01-23
The influence of HLA genotype on the severity of COVID-19 infection
David J. Langton, Stephen C. Bourke, Benedicte A. Lie, Gabrielle Reiff,
Shonali Natu, Rebecca Darlay, John Burn and Carlos Echevarria
HLA Immune Response Genetics 2021-04-19
Association between psoriasis and
rheumatoid arthritis in a nationally representative
population in the United States
, Akshitha Thatiparthi, Jeffrey Liu, Jashin J. Wu.
Journal of the American Academy of Dermatology Letter
(Dr Wu has kindly sent me a copy of this article.)
A carefully conducted survey found that 8.1% of people with psoriasis
reported a history of RA, while such a history was reported by only
4.0% of people without psoriasis. The OR for these findings
varied from 2.82 for subjects aged 20 to 49 and 1.64 for subjects aged
50 and above. The authors write:
This association may be attributed to a similar pathophysiology, with
tumor necrosis factor-alpha and
interleukin 17 implicated in both the disorders. Interestingly,
tumor necrosis factor-alpha inhibitors have been reported to
paradoxically induce and/or worsen psoriasis, most commonly, in
individuals with RA or Crohn disease.
© 2021 Robin Whittle Daylesford, Victoria, Australia